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Phenylalanine, tyrosine and tryptophan biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
phenylpyruvate + acetyl-CoA + H2O <=> 2-Benzylmalate + CoA + H+ 2.3.3
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2-Benzylmalate <=> 3-Benzylmalate 4.2.1
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L-arogenate + oxaloacetate <=> prephenate + L-aspartate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
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prephenate + NAD+ <=> 4-hydroxyphenylpyruvate + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.13 prephenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
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–
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H+ + 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate <=> indole-3-glycerol_phosphate + CO2 + H2O 4.1.1.48 indole-3-glycerol-phosphate synthase
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L-arogenate + NADP+ <=> L-tyrosine + CO2 + NADPH 1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
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H+ + prephenate <=> phenylpyruvate + H2O + CO2 4.2.1.51 prephenate dehydratase
4.2.1.91 arogenate dehydratase
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L-tyrosine + pyruvate <=> 4-hydroxyphenylpyruvate + L-alanine 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.5 tyrosine transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.58 phenylalanine(histidine) transaminase
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5-enolpyruvylshikimate_3-phosphate <=> phosphate + chorismate 4.2.3.5 chorismate synthase
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ <=> 3-dehydroquinate + NH3 + NADH + H+ 1.4.1.24 3-dehydroquinate synthase II
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L-phenylalanine + NAD+ + H2O <=> phenylpyruvate + NH3 + NADH + H+ 1.4.1.1 alanine dehydrogenase
1.4.1.19 tryptophan dehydrogenase
1.4.1.20 phenylalanine dehydrogenase
1.4.1.5 L-amino-acid dehydrogenase
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase
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chorismate + NH3 <=> anthranilate + pyruvate + H2O 4.1.3.27 anthranilate synthase
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3-dehydroquinate <=> H2O + 3-dehydroshikimate 4.2.1.10 3-dehydroquinate dehydratase
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3-phosphoshikimate + phosphoenolpyruvate <=> 5-enolpyruvylshikimate_3-phosphate + phosphate 2.5.1.19 3-phosphoshikimate 1-carboxyvinyltransferase
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shikimate + NAD+ <=> 3-dehydroshikimate + NADH + H+ 1.1.1.166 hydroxycyclohexanecarboxylate dehydrogenase
1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase
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quinate + pyrroloquinoline_quinone <=> 3-dehydroquinate + reduced_pyrroloquinoline_quinone 1.1.5.8 quinate dehydrogenase (quinone)
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3-Benzylmalate + NAD+ <=> 2-oxo-4-phenylbutanoic_acid + CO2 + NADH 1.1.1
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methylglyoxal + D-Fructose_1-phosphate <=> D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate 2.2.1.11 6-deoxy-5-ketofructose 1-phosphate synthase
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chorismate <=> 3-hydroxybenzoate + pyruvate 4.1.3.45 3-hydroxybenzoate synthase
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chorismate <=> prephenate 5.4.99.5 chorismate mutase
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shikimate + ATP <=> H+ + 3-phosphoshikimate + ADP 2.7.1.71 shikimate kinase
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L-tyrosine + H2O + NAD+ <=> 4-hydroxyphenylpyruvate + NH3 + NADH 1.4.1.20 phenylalanine dehydrogenase
1.4.1.5 L-amino-acid dehydrogenase
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phosphoenolpyruvate + D-erythrose_4-phosphate + H2O <=> 3-deoxy-D-arabino-hept-2-ulosonate_7-phosphate + phosphate 2.5.1.54 3-deoxy-7-phosphoheptulonate synthase
2.5.1.55 3-deoxy-8-phosphooctulonate synthase
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3-deoxy-D-arabino-hept-2-ulosonate_7-phosphate <=> 3-dehydroquinate + phosphate 4.2.1.10 3-dehydroquinate dehydratase
4.2.3.4 3-dehydroquinate synthase
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L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.49 dihydroxyphenylalanine transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase
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1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate + L-aspartate_4-semialdehyde <=> 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl_phosphate 2.2.1.10 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
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indole-3-glycerol_phosphate + L-serine <=> L-tryptophan + H2O + D-glyceraldehyde_3-phosphate 4.2.1.20 tryptophan synthase
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chorismate + L-glutamine <=> H+ + anthranilate + L-glutamate + pyruvate 4.1.3.27 anthranilate synthase
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L-tyrosine + H2O + O2 <=> 4-hydroxyphenylpyruvate + NH3 + H2O2 1.4.3.11 L-glutamate oxidase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
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chorismate + H2O <=> (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate 3.3.2.13 chorismatase
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L-phenylalanine + O2 + H2O <=> phenylpyruvate + NH3 + H2O2 + H+ 1.13.12.9 phenylalanine 2-monooxygenase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
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L-phenylalanine + 2-oxoglutarate <=> phenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.70 aspartate---phenylpyruvate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase
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shikimate + NADP+ <=> 3-dehydroshikimate + NADPH + H+ 1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase
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L-arogenate + NAD+ <=> L-tyrosine + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
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–
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quinate + NAD+ <=> 3-dehydroquinate + NADH + H+ 1.1.1.166 hydroxycyclohexanecarboxylate dehydrogenase
1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase
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H+ + L-arogenate <=> CO2 + H2O + L-phenylalanine 4.2.1.51 prephenate dehydratase
4.2.1.91 arogenate dehydratase
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methylglyoxal + D-fructose_1,6-bisphosphate <=> D-glyceraldehyde_3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate 2.2.1.11 6-deoxy-5-ketofructose 1-phosphate synthase
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L-serine + indole <=> L-tryptophan + H2O 4.1.99.1 tryptophanase
4.2.1.122 tryptophan synthase (indole-salvaging)
4.2.1.20 tryptophan synthase
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2-oxo-4-phenylbutanoic_acid + an_L-amino_acid <=> L-homophenylalanine + a_2-oxo_carboxylate 2.6.1
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N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate 5.3.1.24 phosphoribosylanthranilate isomerase
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L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + dihydrobiopterin + H2O 1.14.16.1 phenylalanine 4-monooxygenase
1.14.16.4 tryptophan 5-monooxygenase
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indole-3-glycerol_phosphate <=> indole + D-glyceraldehyde_3-phosphate 4.1.2.8 indole-3-glycerol-phosphate lyase
4.2.1.20 tryptophan synthase
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L-arogenate + 2-oxoglutarate <=> prephenate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
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quinate + NADP+ <=> 3-dehydroquinate + NADPH + H+ 1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase
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shikimate + pyrroloquinoline_quinone <=> 3-dehydroshikimate + reduced_pyrroloquinoline_quinone 1.1.5.8 quinate dehydrogenase (quinone)
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L-phenylalanine + pyruvate <=> phenylpyruvate + L-alanine 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.15 glutamine---pyruvate transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.58 phenylalanine(histidine) transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
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N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate <=> anthranilate + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.18 anthranilate phosphoribosyltransferase
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prephenate + NADP+ <=> 4-hydroxyphenylpyruvate + CO2 + NADPH 1.3.1.12 prephenate dehydrogenase
1.3.1.13 prephenate dehydrogenase (NADP+)
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
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